Surface‐Attached Polymer Networks Made from Cationic Poly(diitaconates): Synthesis, Surface Characterization, and Bioactivity

Facially amphiphilic polymers carrying cationic and hydrophobic groups on the same repeat unit have shown promising antimicrobial activity biocompatibility, yet they are prone to suffer from protein adhesion which may induce biofilm formation. To overcome this problem, poly(diitaconate)-based copolymers with cationic/hydrophobic protein-repellent/charge-neutral units synthesized. The bioactivity profile of surface-attached polymer networks made these depends ratio charge-neutral units. In all cases, is substantially reduced compared purely polymers. At a 50:50 ratio, coatings partially protein-repellent antimicrobial, slightly cell toxic. an intermediate composition 30:70, still compatibility improved. long-term stability materials has be determined judge their suitability for medical applications.